[PAX-6 gene promoter polymorphism and other factors involved in brain atrophy in alcohol dependent patients].

نویسندگان

  • Jerzy Samochowiec
  • Jolanta Kucharska-Mazur
  • Jan Horodnicki
  • Klaus Peter Lesch
  • Hans Rommelspacher
  • Lutz Gerhard Schmidt
چکیده

PAX-6 gene promoter polymorphism, alcohol dependence history and CT were determined in the group of 68 alcoholics. We found negative correlation between numbers of PAX-6 gene promoter B (AC)m (AG)n repeats and atrophy of the brain and the cerebellum. Occurrence of these lesions was correlated with a decrease of alcohol tolerance, withdrawal symptoms--especially delirium tremens.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Genetic polymorphisms in the promoter region of catalase gene, creates new potential PAX-6 and STAT4 response elements

Catalase (CAT, OMIM: 115500) is an endogenous antioxidant enzyme and genetic variations in the regulatory regions of the CAT gene may alter the CAT enzyme activity and subsequently may alter the risk of oxidative stress related disease. In this study, potential influence(s) of the A-21T (rs7943316) and C-262T (rs1001179) genetic polymorphisms in the CAT promoter region, using the ALGGEN-PROMO.v...

متن کامل

P-160: Study of Association between Polymorphism in Estrogen Response Element (ERE) in Promoter Region of C3 Gene and Spontaneous Recurrent Abortion

Background: There are different etiological factors in spontaneous recurrent abortion which are one of the complications in pregnancy. Primary embryo development in uterine tube and oviduct are affected by different factors such as embryotrophic elements. ETF3 as a embryotrophic factor that contains a complex of complement 3 protein and its derivatives specially iC3b, causes embryo trophoblast ...

متن کامل

Investigating the relationship between C-159T polymorphism in CD14 gene promoter and disease severity in 2019 corona virus patients

Introduction: Considering the effectiveness of polymorphisms in the occurrence of respiratory diseases, it seems that these genetic variations in viral and microbial receptors can be effective in the occurrence and progression of the disease. The present study aimed to  assess the relationship between the C-159T polymorphism in the CD14 gene promoter and the severity of the disease in  Covid-19...

متن کامل

Association of the -160 C>A Polymorphism in the CDH1 Promoter with Gastric Cancer: A Case-control Study

E-cadherin is a tumor suppressor protein that plays a crucial role in cell-cell adherens junction and tissue architecture and it is hypothesized to participate in carcinogenesis. It has been shown that a polymorphism in the upstream of the transcription start site of the CDH1 gene affects E-cadherin transcriptional regulation and seems to be associated with a variety of cancers. For the first t...

متن کامل

Cytokine Gene Polymorphism in BCG Lymphadenopathy

Background: Tumor necrosis factor-beta or lymphotoxin-alpha (LT-α), IL-4 and IL-10 are determining factors in immunity against BCG.  Allelic polymorphisms in the regulatory regions of their genes affect the rate of cytokine production and therefore, the host’s ability in BCG containment. Objective: To study the prevalence of –590 (C/T) and –592 (C/A) allelic distribution of IL-4 and IL-10 promo...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Psychiatria polska

دوره 36 2  شماره 

صفحات  -

تاریخ انتشار 2002